论文标题
使用生物物理方法来理解睫毛跳动
The use of biophysical approaches to understand ciliary beating
论文作者
论文摘要
纤毛运动是功能性细胞细胞器的一个惊人例子，在所有真核物种中保守。纤毛纤毛允许细胞和小生物游泳以及液体在上皮组织中的运输。尽管现在已经非常了解分子结构，但纤毛的动力学在单一纤毛水平或集体跳动水平上都无法得到很好的确定。实际上，对此充分理解需要将各个长度尺度的行为连接在一起，从分子到细胞器，然后在细胞水平到组织尺度。除了对该系统的基本兴趣外，理解跳动对于阐明胚胎发育的各个方面以及从生育到气道遗传和传染病的各种健康状况至关重要。
Motile cilia are a striking example of functional cellular organelle, conserved across all the eukaryotic species. Motile cilia allow swimming of cells and small organisms and transport of liquids across epithelial tissues. Whilst the molecular structure is now very well understood, the dynamics of cilia is not well established either at the single cilium level nor at the level of collective beating. Indeed, a full understanding of this requires connecting together behaviour across various lengthscales, from the molecular to the organelle, then at cellular level and up to the tissue scale. Aside from the fundamental interest in this system, understanding beating is important to elucidate aspects of embryonic development and a variety of health conditions from fertility to genetic and infectious diseases of the airways.
