论文标题

神经元相互作用

Neuron-Glial Interactions

论文作者

De Pittà, Maurizio

论文摘要

尽管在经典的计算神经科学背后落后,但理论和计算方法开始出现,以表征神经元相互作用的不同方面。本章旨在提供有关哺乳动物大脑中神经元相互作用的基本知识,并利用侧重于健康大脑中这种相互作用的结构(解剖学)和功能(生理)的计算研究。尽管我们对大脑中神经元相互作用的需求的理解仍处于起步阶段,但主要基于等待实验验证的预测,但引入了从控制理论中借用的简单的一般建模参数,以支持将这种相互作用纳入传统神经元基于传统的基于神经元的建模范式的重要性。

Although lagging behind classical computational neuroscience, theoretical and computational approaches are beginning to emerge to characterize different aspects of neuron-glial interactions. This chapter aims to provide essential knowledge on neuron-glial interactions in the mammalian brain, leveraging on computational studies that focus on structure (anatomy) and function (physiology) of such interactions in the healthy brain. Although our understanding of the need of neuron-glial interactions in the brain is still at its infancy, being mostly based on predictions that await for experimental validation, simple general modeling arguments borrowed from control theory are introduced to support the importance of including such interactions in traditional neuron-based modeling paradigms.

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