论文标题
通过平行孔和针孔光学元件，非标准MBI系统的角度层析成像重建有限
Limited Angle Tomography reconstruction for non-standard MBI system by means of parallel-hole and pinhole optics
论文作者
论文摘要
本工作的目的是研究新的分子乳房成像（MBI）设备的重建特性，用于以有限的角度层析成像（LAT）的早期诊断，通过使用两个具有不同准直剂的不对称探测器头。探测器以反平行的观看方向互相面对，并在轻度压缩乳房幻象上，能够使用专用的最大可能性期望最大化（ML-EM）算法来重建幻影的内部肿瘤。简要介绍了使用Geant 4应用层析成像发射（GATE）软件的幻影，MBI系统以及蒙特卡洛模拟器。 MBI系统的模型已在IDL（交互式数据可视化）中实现，以通过改变肿瘤的大小，深度和摄取来评估系统的最佳LAT配置及其重建能力。讨论了以真实和模拟配置以及ML-EM方法和初步重建结果中的LAT设置。
The purpose of the present work is the study of reconstruction properties of a new Molecular Breast Imaging (MBI) device for the early diagnosis of breast cancer, in Limited Angle Tomography (LAT), by using two asymmetric detector heads with different collimators. The detectors face each other in anti-parallel viewing direction and, mild-compressing the breast phantom, they are able to reconstruct the inner tumour of the phantoms with only a limited number of projections using a dedicated maximum-likelihood expectation maximization (ML-EM) algorithm. Phantoms, MBI system, as well as Monte Carlo simulator using Geant 4 Application for Tomographic Emission (GATE) software, are briefly described. MBI system's model has been implemented in IDL (Interactive Data Visualization), in order to evaluate the best LAT configuration of the system and its reconstruction ability by varying tumour's size, depth and uptake. LAT setup in real and simulated configurations, as well as the ML-EM method and the preliminary reconstruction results, are discussed.
