论文标题
基于DNA扭转的细胞命运相变模型
DNA Torsion-based Model of Cell Fate Phase Transitions
论文作者
论文摘要
可以从细胞命运的统一理论模型中理解所有干细胞命运转变，包括干细胞的代谢重编程和成纤维细胞向多能干细胞的体细胞重编程。每个细胞命运跃迁都可以视为DNA超螺旋中的相变。但是，已经缺乏定量生物物理模型来解释和预测这些相变的行为。提出了广义的ISING模型来定义此类相变。该模型预测，除了温度引起的相变，还存在DNA扭转频率诱导的相变。从干细胞激活到分化和重编程的表观遗传状态的主要过渡可以通过这种扭转频率诱导的相变的解释，对将来的再生医学和医学诊断具有重要意义。
All stem cell fate transitions, including the metabolic reprogramming of stem cells and the somatic reprogramming of fibroblasts into pluripotent stem cells, can be understood from a unified theoretical model of cell fates. Each cell fate transition can be regarded as a phase transition in DNA supercoiling. However, there has been a dearth of quantitative biophysical models to explain and predict the behaviors of these phase transitions. The generalized Ising model is proposed to define such phase transitions. The model predicts that, apart from temperature-induced phase transitions, there exists DNA torsion frequency-induced phase transitions. Major transitions in epigenetic states, from stem cell activation to differentiation and reprogramming, can be explained by such torsion frequency-induced phase transitions, with important implications for regenerative medicine and medical diagnostics in the future.
