论文标题
由组成 - 曲面耦合诱导的双成分囊泡中的结构域形成
Domain formation in bicomponent vesicles induced by composition-curvature coupling
论文作者
论文摘要
通过密集的蒙特卡洛数值模拟研究了由两种类型脂质组成的混合物组成的脂质囊泡。局部组成和膜形之间的耦合是由组件的两个不同的自发曲率诱导的。我们探索了这些双相囊泡的各种形态，该囊泡与观察到的模式（例如纳米域或迷宫中的中间酶）结合在一起。彻底探索了曲率差异，表面张力和相互作用参数的影响。我们的数值结果与[Gueguen等，Eur。物理。 J. E，2014年，第一卷。 37，第37页。 76]在无序（高温）阶段。数值模拟使我们能够探索完整的参数空间，尤其是在临界温度附近和低于分析结果的地方。构建相图并通过计算结构因子和域尺寸分布来定量研究域形态。这种机制可能解释了通过超分辨率荧光显微镜观察到的细胞膜中纳米域的存在。
Lipid vesicles composed of a mixture of two types of lipids are studied by intensive Monte-Carlo numerical simulations. The coupling between the local composition and the membrane shape is induced by two different spontaneous curvatures of the components. We explore the various morphologies of these biphasic vesicles coupled to the observed patterns such as nano-domains or labyrinthine mesophases. The effect of the difference in curvatures, the surface tension and the interaction parameter between components are thoroughly explored. Our numerical results quantitatively agree with previous analytical results obtained by [Gueguen et al., Eur. Phys. J. E, 2014, vol. 37, p. 76] in the disordered (high temperature) phase. Numerical simulations allow us to explore the full parameter space, especially close to and below the critical temperature, where analytical results are not accessible. Phase diagrams are constructed and domain morphologies are quantitatively studied by computing the structure factor and the domain size distribution. This mechanism likely explains the existence of nano-domains in cell membranes as observed by super-resolution fluorescence microscopy.
