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A random dot product graph (RDPG) is a generative model for networks in which vertices correspond to positions in a latent Euclidean space and edge probabilities are determined by the dot products of the latent positions. We consider RDPGs for which the latent positions are randomly sampled from an unknown $1$-dimensional submanifold of the latent space. In principle, restricted inference, i.e., procedures that exploit the structure of the submanifold, should be more effective than unrestricted inference; however, it is not clear how to conduct restricted inference when the submanifold is unknown. We submit that techniques for manifold learning can be used to learn the unknown submanifold well enough to realize benefit from restricted inference. To illustrate, we test $1$- and $2$-sample hypotheses about the Fréchet means of small communities of vertices, using the complete set of vertices to infer latent structure. We propose test statistics that deploy the Isomap procedure for manifold learning, using shortest path distances on neighborhood graphs constructed from estimated latent positions to estimate arc lengths on the unknown $1$-dimensional submanifold. Unlike conventional applications of Isomap, the estimated latent positions do not lie on the submanifold of interest. We extend existing convergence results for Isomap to this setting and use them to demonstrate that, as the number of auxiliary vertices increases, the power of our test converges to the power of the corresponding test when the submanifold is known. Finally, we apply our methods to an inference problem that arises in studying the connectome of the Drosophila larval mushroom body. The univariate learnt manifold test rejects ($p<0.05$), while the multivariate ambient space test does not ($p\gg0.05$), illustrating the value of identifying and exploiting low-dimensional structure for subsequent inference.