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Cancer is one of the most common diseases worldwide, posing a serious threat to human health and leading to the deaths of a large number of people. It was observed during the drug administration in chemotherapy that immune cells, cancer cells and normal cells are killed or at least seriously injured and also in order to keep dosage of the drug at specific level in body, drug should be delivered in specific time and dosage. Therefore, to address these problems, a decision-making process is needed to identify the most appropriate treatment for cancer cases which causes killing of cancer cells by considering the number of healthy cells that would be killed. Despite the latest technological developments, the current methods need to be improved to suggest the most optimized a dose of the drug for tumor cells discretely. It is expected that our proposed ANFIS model be able to suggest the specialists the most optimum dose of the drug, which considers all key factors including cancer cells, immune and health cells. The results of the simulations exhibit the high accuracy of the proposed intelligent controller during the treatment in predicting the behavior of all key factors and minimize the usage dose of the drug with regard this significant point that the proposed controller gives discrete data for treatment which can fill the gap between engineering and medical science.