论文标题
相关平衡网络中的突触可塑性
Synaptic Plasticity in Correlated Balanced Networks
论文作者
论文摘要
局部皮质网络的动力学不规则,但相关。动态兴奋性 - 抑制平衡是一种合理的机制,它会产生这种不规则的活性,但尚不清楚如何在塑料神经网络中实现和维持平衡。特别是,尚不完全了解可塑性引起的网络变化如何影响平衡,而相关,平衡的活动如何影响学习。在不同的可塑性规则下,平衡网络的动态如何变化?复发网络中的尖峰活动如何改变权重的演变,其最终的大小和整个网络的结构?为了解决这些问题,我们在平衡网络中发展了可塑性的一般理论。我们表明,可以在可塑性引起的体重变化下达到和维持平衡。我们发现输入中的相关性温和,但显着影响突触权重的演变。根据某些可塑性规则,我们发现点火速率和突触权重之间的相关性出现。根据这些规则,突触权重与重量空间中的稳定歧管收敛,其最终配置取决于网络的初始状态。最后,我们表明,当神经元的子集接收到靶向的光遗传学输入时,我们的框架还可以描述塑料平衡网络的动力学。
The dynamics of local cortical networks are irregular, but correlated. Dynamic excitatory--inhibitory balance is a plausible mechanism that generates such irregular activity, but it remains unclear how balance is achieved and maintained in plastic neural networks. In particular, it is not fully understood how plasticity induced changes in the network affect balance, and in turn, how correlated, balanced activity impacts learning. How does the dynamics of balanced networks change under different plasticity rules? How does correlated spiking activity in recurrent networks change the evolution of weights, their eventual magnitude, and structure across the network? To address these questions, we develop a general theory of plasticity in balanced networks. We show that balance can be attained and maintained under plasticity induced weight changes. We find that correlations in the input mildly, but significantly affect the evolution of synaptic weights. Under certain plasticity rules, we find an emergence of correlations between firing rates and synaptic weights. Under these rules, synaptic weights converge to a stable manifold in weight space with their final configuration dependent on the initial state of the network. Lastly, we show that our framework can also describe the dynamics of plastic balanced networks when subsets of neurons receive targeted optogenetic input.