论文标题
用于癌症放射疗法的毫米级单电荷粒子剂量计
A Millimeter-scale Single Charged Particle Dosimeter for Cancer Radiotherapy
论文作者
论文摘要
本文提出了一个毫米级的CMOS 64 $ \ times $ 64用于外束癌放射疗法的单电荷颗粒辐射探测器系统。 1 $ \ times $ 1 $μm^2 $二极管测量耗尽区域中的一个充电粒子的能量沉积，并且数组设计提供了512 $ \ times $ 512 $ 512 $μm^2 $的大检测区域。所提出的系统没有感知辐射引起的电压降，而是测量脉冲宽度，即电压返回其基线所需的时间。这消除了使用耗电和大型类似于数字的转换器的需求。在TSMC 65 nm LP CMOS工艺中制造了原型ASIC，并消耗了0.535 MW的平均静电功率，低于1.2 V模拟和数字电源。在临床67.5 MEV质子束设置中，整个系统的功能已成功验证。据我们所知，这是第一项证明用于植入体内剂量测定法的单个带电颗粒检测的工作。
This paper presents a millimeter-scale CMOS 64$\times$64 single charged particle radiation detector system for external beam cancer radiotherapy. A 1$\times$1 $μm^2$ diode measures energy deposition by a single charged particle in the depletion region, and the array design provides a large detection area of 512$\times$512 $μm^2$. Instead of sensing the voltage drop caused by radiation, the proposed system measures the pulse width, i.e., the time it takes for the voltage to return to its baseline. This obviates the need for using power-hungry and large analog-to-digital converters. A prototype ASIC is fabricated in TSMC 65 nm LP CMOS process and consumes the average static power of 0.535 mW under 1.2 V analog and digital power supply. The functionality of the whole system is successfully verified in a clinical 67.5 MeV proton beam setting. To our' knowledge, this is the first work to demonstrate single charged particle detection for implantable in-vivo dosimetry.
