论文标题
循环流介导的组织衰竭传播
Tissue failure propagation as mediated by circulatory flow
论文作者
论文摘要
衰老是由相对理解的亚细胞过程驱动的。然而，这些微观级别失败如何在组织或器官中级别灾难级联的定性机制和定量动力学仍然在很大程度上尚未得到探索。在这里，我们在实验和理论上研究了在存在对流的情况下如何在合成组织中传播细胞衰竭。我们认为细胞会分泌合作因素，从而形成了一个相互依赖的网络，该网络受扩散和流动的控制，该网络在与循环平行的繁殖前部失败。
Aging is driven by subcellular processes that are relatively well-understood. However the qualitative mechanisms and quantitative dynamics of how these micro-level failures cascade to a macro-level catastrophe in a tissue or organs remain largely unexplored. Here we experimentally and theoretically study how cell failure propagates in a synthetic tissue in the presence of advective flow. We argue that cells secrete cooperative factors, thereby forming a network of interdependence governed by diffusion and flow, which fails with a propagating front parallel to advective circulation.
