论文标题
通过共聚焦成像，由于全身照射而导致DNA特异性空间质量密度波动的光子学探测DNA特异性空间质量密度波动
Photonics probing of DNA specific spatial mass density fluctuations in gut cell nuclei due to total body irradiation via confocal imaging
论文作者
论文摘要
细胞内的异常导致纳米级结构改变可以通过共聚焦成像和对这些改变的定量进行表征。意外或故意暴露于全身辐射（TBI）对细胞的核DNA有不利影响。在这里，我们使用称为共聚焦图像中称为逆参与率（IPR）的光定位技术，研究由暴露于4GY TBI的标准剂量引起的肠道组织中染色质的DNA分子质量密度空间结构改变。结果表明辐射抑制了DNA空间质量密度波动。因此，在不同的辐照持续时间内观察到DNA密度波动的降低和饱和。
Abnormalities within cells result in nanoscale structural alterations can be characterized via confocal imaging and quantification of these alterations. Accidental or deliberate exposure to total body irradiation (TBI) have adverse effects on the nuclear DNAs of cells. Here, we study the DNA molecular mass density spatial structural alterations of chromatin in cell nuclei of gut tissues caused by the exposure to standard doses of 4Gy TBI, using the light localization technique called inverse participation ratio (IPR) in confocal images. Results indicate radiation suppresses DNA spatial mass density fluctuations. And hence, reduction and saturation in DNA density fluctuations are observed for different durations of post-irradiation.
