论文标题
亨廷顿氏病持续发音的声音标记
Vocal markers from sustained phonation in Huntington's Disease
论文作者
论文摘要
目前在神经退行性疾病中评估了疾病改良治疗。亨廷顿氏病也代表了设计自动次临床标记物的独特机会，即使在premanifest基因携带者中也是如此。我们将语音障碍作为潜在的临床标记进行了研究，并提出了诊断和基因载体随访的提议。我们使用了两组功能：语音功能和调制功率谱特征。我们发现，发音不足以鉴定前命中率基因载体的亚临床疾病。根据我们的回归结果，语音特征适合预测亨廷顿氏病临床表现。
Disease-modifying treatments are currently assessed in neurodegenerative diseases. Huntington's Disease represents a unique opportunity to design automatic sub-clinical markers, even in premanifest gene carriers. We investigated phonatory impairments as potential clinical markers and propose them for both diagnosis and gene carriers follow-up. We used two sets of features: Phonatory features and Modulation Power Spectrum Features. We found that phonation is not sufficient for the identification of sub-clinical disorders of premanifest gene carriers. According to our regression results, Phonatory features are suitable for the predictions of clinical performance in Huntington's Disease.
