论文标题
多边缘WASSERSTEIN BARYCENTER用于染色标准化和增强
Multimarginal Wasserstein Barycenter for Stain Normalization and Augmentation
论文作者
论文摘要
苏木精和曙红（H＆E）染色图像（由于临床实验室方案，扫描仪等）的变化直接影响临床诊断的质量和准确性，因此，控制这些变化以进行可靠的诊断很重要。在这项工作中，我们提出了一种基于多边形瓦斯坦堡的新方法，以标准化和增强一个或多个参考的H＆E染色图像。具体而言，我们提供了一种自然合并其他图像作为中间参考的数学强大方法，以同时驱动染色归一化和增强。与最新的染色方法相比，提出的方法在定量和定性上显示出了优越的结果。我们进一步验证了公开可用数据集中的核分割任务中的污渍归一化和增强，从而针对竞争方法实现了最新的结果。
Variations in hematoxylin and eosin (H&E) stained images (due to clinical lab protocols, scanners, etc) directly impact the quality and accuracy of clinical diagnosis, and hence it is important to control for these variations for a reliable diagnosis. In this work, we present a new approach based on the multimarginal Wasserstein barycenter to normalize and augment H&E stained images given one or more references. Specifically, we provide a mathematically robust way of naturally incorporating additional images as intermediate references to drive stain normalization and augmentation simultaneously. The presented approach showed superior results quantitatively and qualitatively as compared to state-of-the-art methods for stain normalization. We further validated our stain normalization and augmentations in the nuclei segmentation task on a publicly available dataset, achieving state-of-the-art results against competing approaches.
