论文标题
内在无序蛋白质构建体中的玻璃动力学和记忆效应
Glassy dynamics and memory effects in an intrinsically disordered protein construct
论文作者
论文摘要
球状蛋白质中的玻璃状，非分数松弛通常归因于本质上无序蛋白缺失的构象行为。然而，我们表明，无序蛋白质构建体的单分子显示了两个玻璃动力学的签名，对数松弛和科瓦奇记忆效应，以响应施加的张力的变化。我们将其归因于链中多个独立的局部结构的存在，我们用正确预测弛豫力依赖性的模型证实了这一点。这里建立的机制可能适用于其他无序蛋白质。
Glassy, nonexponential relaxations in globular proteins are typically attributed to conformational behaviors that are missing from intrinsically disordered proteins. Yet, we show that single molecules of a disordered-protein construct display two signatures of glassy dynamics, logarithmic relaxations and a Kovacs memory effect, in response to changes in applied tension. We attribute this to the presence of multiple independent local structures in the chain, which we corroborate with a model that correctly predicts the force dependence of the relaxation. The mechanism established here likely applies to other disordered proteins.
