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It has become very essential to address the limited spectrum capacity and their efficient utilization to support the increasing number of Internet of Things devices. When it comes to medical infrastructure, it becomes very imperative for medical devices to communicate with the base station. In such situations, communication over the wireless medium must provide optimized throughput (data rate) with effectual energy usage, which will ensure precise medical feedback by the responsible staff. Taking into account, it is necessary to operate wireless communication precisely at a higher frequency with more substantial bandwidth and low latency. Cognitive Radio (CR) is traditionally a viable choice, where it identifies and utilizes the vacant spectrum, thus maximizing the primary user's capacity and achieving spectral efficiency. To ensure such outcomes, the Non-Orthogonal Multiple Access (NOMA) techniques have proven to deliver an effective solution to the increasing number of devices with unimpaired performance, especially when the communication shifts towards a higher frequency band such as the mmWave band. In this chapter, IoT based CR network in uplink communication is proposed alongside employing NOMA techniques for optimal throughput, and energy efficiency for a medical infrastructure. Numerical results show that effectual throughput and energy efficiency for a High Reliable Communication (HRC) device and Moderate Reliable Communication (MRC) device improve over 83.13% and 73.95%, respectively and their corresponding energy efficacy values show vast improvement (83.11% and 73.96% respectively). Likewise, for interference case both the throughput and the energy efficiency improve approximately over 93% for all devices.