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Mobile health (mHealth) applications (apps) have gained significant popularity over the last few years due to its tremendous benefits, such as lowering healthcare cost and increasing patient awareness. However, the sensitivity of healthcare data makes the security of mHealth apps a serious concern. In this review, we aim to identify and analyse the reported challenges that the developers of mHealth apps face concerning security. Additionally, our study aimed to develop a conceptual framework with the challenges faced by mHealth apps development organization for developing secure apps. The knowledge of such challenges can help to reduce the risk of developing insecure mHealth apps. We followed the Systematic Literature Review method for this review. We selected studies that have been published between January 2008 and October 2020. We selected 32 primary studies using predefined criteria and used thematic analysis method for analysing the extracted data. We identified nine challenges that can affect the development of secure mHealth apps. Such as 1) lack of security guidelines and regulations for developing secure mHealth apps, 2) developers lack of knowledge and expertise for secure mHealth app development, 3) lack of stakeholders involvement during mHealth app development, etc . Based on our analysis, we have presented a conceptual framework which highlights the correlation between the identified challenges. We conclude that our findings can help them identify their weaknesses and improve their security practices. Similarly, mHealth apps developers can identify the challenges they face to develop mHealth apps that do not pose security risks for users. Our review is a step towards providing insights into the development of secure mHealth apps. Our proposed conceptual framework can act as a practice guideline for practitioners to enhance secure mHealth apps development.