论文标题
新生粘附研究的最新进展和前景
Recent Advances and Prospects in the Research of Nascent Adhesions
论文作者
论文摘要
新生的粘附是促进细胞对细胞外基质的早期粘附的亚微米瞬态结构。新生的粘附通常由几十个整合素组成，并用作募集和激活蛋白质以构建成熟局灶性粘附的平台。它们还与早期信号传导和机械响应有关。尽管它们在抽样局部细胞外基质中的作用至关重要，但对它们形成的机制知之甚少。因此，有一项强大的科学活动着重于阐明其发展和功能的物理和生化基础。正是本文将总结这项工作的结果。
Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and activation of proteins to build mature focal adhesions. They are also associated with early stage signalling and the mechanoresponse. Despite their crucial role in sampling the local extracellular matrix, very little is known about the mechanism of their formation. Consequently, there is a strong scientific activity focused on elucidating the physical and biochemical foundation of their development and function. Precisely the results of this effort will be summarized in this article.
