论文标题
超级宣传事件表明，通过在封闭空间中积累来使SARS-COV-2的气溶胶传播
Superspreading events suggest aerosol transmission of SARS-CoV-2 by accumulation in enclosed spaces
论文作者
论文摘要
病毒传播途径对公共安全具有深远的影响；因此，必须完全了解可行的传染途径。越来越多的证据表明，SARS-COV-2可以通过空气传播。但是，这尚未得到证明。在这里，我们通过考虑雾化的病毒体发射和不稳定来定量分析病毒粒子的积累。报道了在此框架内分析的超广播事件，该事件涉及气溶胶介导的SARS-COV-2传播。发现针对这些事件计算的病毒体暴露是发现单个值的，这表明通过气溶胶的通用最小感染剂量（MID）与其他呼吸道病毒测量的MID相媲美。因此，一致的传染性暴露水平及其对已知气溶胶中的相当性建立了SARS-COV-2的气溶胶传播的合理性。以超过雾化SARS-COV-2的不稳定速率的过滤速率可以降低暴露于此感染剂量以下。
Viral transmission pathways have profound implications for public safety; it is thus imperative to establish a complete understanding of viable infectious avenues. Mounting evidence suggests SARS-CoV-2 can be transmitted via the air; however, this has not yet been demonstrated. Here we quantitatively analyze virion accumulation by accounting for aerosolized virion emission and destabilization. Reported superspreading events analyzed within this framework point towards aerosol mediated transmission of SARS-CoV-2. Virion exposure calculated for these events is found to trace out a single value, suggesting a universal minimum infective dose (MID) via aerosol that is comparable to the MIDs measured for other respiratory viruses; thus, the consistent infectious exposure levels and their commensurability to known aerosol-MIDs establishes the plausibility of aerosol transmission of SARS-CoV-2. Using filtration at a rate exceeding the destabilization rate of aerosolized SARS-CoV-2 can reduce exposure below this infective dose.
