论文标题
皮肤健康和疾病中的内源性和微生物挥发性有机化合物
Endogenous and microbial volatile organic compounds in cutaneous health and disease
论文作者
论文摘要
人皮肤是一个具有高代谢活性的区域，其中有很多生物标志物从角质层分泌。皮肤是源自皮肤腺体和常驻微生物群的挥发性有机化合物（VOC）的恒定来源。皮肤VOC包含细胞活性的足迹，因此为皮肤生理的复杂过程提供了独特的见解。这篇评论研究了与皮肤生理学相关的皮肤VOC标记研究的越来越多的研究，从而使皮肤内部和微生物代谢过程的变化产生了独特的挥发性特征。研究了与皮肤扰动和皮肤癌相关的挥发性生物标志物的新兴证据。还研究了微生物衍生的VOC作为前瞻性诊断标记物，并考虑了它们塑造局部皮肤微生物群的组成的潜力，并因此考虑了皮肤健康。最后，提出了对新兴的分析挑战和基于皮肤VOC的研究和诊断的机会的简短前景。
Human skin is a region of high metabolic activity where a rich variety of biomarkers are secreted from the stratum corneum. The skin is a constant source of volatile organic compounds (VOCs) derived from skin glands and resident microbiota. Skin VOCs contain the footprints of cellular activities and thus offer unique insights into the intricate processes of cutaneous physiology. This review examines the growing body of research on skin VOC markers as they relate to skin physiology, whereby variations in skin-intrinsic and microbial metabolic processes give rise to unique volatile profiles. Emerging evidence for volatile biomarkers linked to skin perturbations and skin cancer are examined. Microbial-derived VOCs are also investigated as prospective diagnostic markers, and their potential to shape the composition of the local skin microbiota, and consequently cutaneous health, is considered. Finally, a brief outlook on emerging analytical challenges and opportunities for skin VOC-based research and diagnostics is presented.
