论文标题
产后抑郁症和环境因素的患病率和发病率：Igedepp队列
Prevalence and incidence of postpartum depression and environmental factors: the IGEDEPP cohort
论文作者
论文摘要
背景：Igedepp（产后基因和抑郁症的抑郁症的相互作用）是一项前瞻性多中心队列研究，对3,310名高加索妇女在2011年至2016年之间出生，并在产后一年。当前研究的目的是描述队列并估计产后早期和晚期抑郁症（PPD）的患病率和累积发生率。方法：在基线时评估了社会人口统计数据，个人和家庭精神病史以及儿童期和怀孕期间的压力性生活事件。使用DSM-5标准，分别在8周和产后1年评估PPD的早期和晚期。结果：PPD早期的患病率为8.3％（95％CI 7.3-9.3），PPD晚期为12.9％（95％CI 11.5-14.2），导致8周的累积发生率为8.5％（95％CI 7.4-9.6），PPD的累积率为PPD，为18.1％1％1％1％。几乎一半的队列（n = 1571，47.5％）至少有一种精神病或成瘾性疾病，主要是抑郁症（35％）。该队列中近300名妇女（9.0％）报告了儿童创伤。怀孕期间，女性有47.7％的妇女经历了压力大的事件，在头8周内30.2％，产后8周和一年之间的43.9％。在8周时，近五分之一的女性报告了至少一个压力后的产后事件。结论：事件抑郁事件在产后第一年影响了近五分之一的女性。大多数妇女都有压力很大的围产期事件。进一步的IGEDEPP研究将旨在消除儿童期和与妊娠有关的压力事件对产后疾病的影响。
Background: IGEDEPP (Interaction of Gene and Environment of Depression during PostPartum) is a prospective multicenter cohort study of 3,310 Caucasian women who gave birth between 2011 and 2016, with follow-up until one year postpartum. The aim of the current study is to describe the cohort and estimate the prevalence and cumulative incidence of early and late postpartum depression (PPD). Methods: Socio-demographic data, personal and family psychiatric history, as well as stressful life events during childhood and pregnancy were evaluated at baseline. Early and late PPD were assessed at 8 weeks and 1 year postpartum respectively, using DSM-5 criteria. Results: The prevalence of early PPD was 8.3% (95%CI 7.3-9.3), and late PPD 12.9% (95%CI 11.5-14.2), resulting in an 8-week cumulative incidence of 8.5% (95%CI 7.4-9.6) and a one-year cumulative incidence of PPD of 18.1% (95%CI: 17.1-19.2). Nearly half of the cohort (N=1571, 47.5%) had a history of at least one psychiatric or addictive disorder, primarily depressive disorder (35%). Almost 300 women in the cohort (9.0%) reported childhood trauma. During pregnancy, 47.7% women experienced a stressful event, 30.2% in the first 8 weeks and 43.9% between 8 weeks and one year postpartum. Nearly one in five women reported at least one stressful postpartum event at 8 weeks. Conclusion: Incident depressive episodes affected nearly one in five women during the first year postpartum. Most women had stressful perinatal events. Further IGEDEPP studies will aim to disentangle the impact of childhood and pregnancy-related stressful events on postpartum mental disorders.
