论文标题
非元素化学反应网络的热力学
Thermodynamics of Non-Elementary Chemical Reaction Networks
论文作者
论文摘要
我们为不需要服从质量动作动力学的非元素反应的封闭和开放化学网络开发了热力学框架。它仅需要动力学和标准化学电位的知识，并利用网络的拓扑特性（保护法律和周期）。如果网络来自更大的基本反应网络，而快速发展的物种是粗粒的，那么我们的方法是准确的。我们的工作应该与很少实现基本动力学表征的生物系统中的能量考虑特别重要。
We develop a thermodynamic framework for closed and open chemical networks applicable to non-elementary reactions that do not need to obey mass action kinetics. It only requires the knowledge of the kinetics and of the standard chemical potentials, and makes use of the topological properties of the network (conservation laws and cycles). Our approach is proven to be exact if the network results from a bigger network of elementary reactions where the fast-evolving species have been coarse grained. Our work should be particularly relevant for energetic considerations in biosystems where the characterization of the elementary dynamics is seldomly achieved.
