论文标题
关于蛋白质空间的广阔
About the Protein Space Vastness
论文作者
论文摘要
鉴于控制IT的因素，对蛋白质空间大小的准确估计是一个长期存在的问题，并且在进化生物学中至关重要，因为它决定了蛋白质可发展性的性质。简单的分析将使我们首先能够减少一个不切实际的蛋白质空间大小〜10^130序列，对于100 residues多肽链，至〜10^9功能蛋白，其次，估计每个氨基酸的平均值稳健的平均值（x〜1.23），并在其上是在蛋白质稳定性的情况下，在蛋白质稳定性的情况下，均可成为蛋白质稳定性，这是蛋白质稳定性的。进化。尽管该结果不能解决蛋白质空间的广泛问题，但将其构成更合理的问题。
An accurate estimation of the Protein Space size, in light of the factors that govern it, is a long-standing problem and of paramount importance in evolutionary biology, since it determines the nature of protein evolvability. A simple analysis will enable us to, firstly, reduce an unrealistic Protein Space size of ~10^130 sequences, for a 100-residues polypeptide chain, to ~10^9 functional proteins and, secondly, estimate a robust average-mutation rate per amino acid (x ~1.23) and infer from it, in light of the protein marginal stability, that only a fraction of the sequence will be available at any one time for a functional protein to evolve. Although this result does not solve the Protein Space vastness problem, frames it in a more rational one.
