论文标题

弹性Cherenkov在横向各向同性软材料I中的效果-I:理论分析,模拟和逆方法

Elastic Cherenkov effects in transversely isotropic soft materials-I: Theoretical analysis, simulations and inverse method

论文作者

Li, Guo-Yang, Zheng, Yang, Liu, Yanlin, Destrade, Michel, Cao, Yanping

论文摘要

正如实验性观察到的那样,浓缩在一个点上并以高速移动的体力可以诱导灰尘 - 血浆晶体或软材料的剪切波锥体,并命名为弹性Cherenkov效应(ECE)。软材料中的ECE构成了超音速剪切成像(SSI)技术的基础,这是一种基于超声的动态弹性方法,近年来应用于诊所。先前对软材料ECE的研究集中在各向同性材料模型上。在本文中,我们通过使用理论分析和有限元(FE)模拟来研究ECE在各向异性软培养基中的存在和关键特征,并将结果应用于生物软组织的非侵入性和非破坏性表征。考虑到超声探针与软组织之间的接触可能会导致有限的变形,理论上还从理论上研究了在变形的超弹性各向异性软材料中引起的剪切波的特征。在我们的理论分析和数值模拟的基础上,我们提出了一种反向方法来推断不可压缩的横向偏射(TI)软材料的各向异性和超弹性参数。最后,我们通过以分析形式得出条件数并执行数值实验来研究逆问题的溶液的性质。在本文的第二部分中,进行了体内和体内实验,以证明逆方法在实际使用中的适用性。

A body force concentrated at a point and moving at a high speed can induce shear-wave Mach cones in dusty-plasma crystals or soft materials, as observed experimentally and named the elastic Cherenkov effect (ECE). The ECE in soft materials forms the basis of the supersonic shear imaging (SSI) technique, an ultrasound-based dynamic elastography method applied in clinics in recent years. Previous studies on the ECE in soft materials have focused on isotropic material models. In this paper, we investigate the existence and key features of the ECE in anisotropic soft media, by using both theoretical analysis and finite element (FE) simulations, and we apply the results to the non=invasive and non-destructive characterization of biological soft tissues. We also theoretically study the characteristics of the shear waves induced in a deformed hyperelastic anisotropic soft material by a source moving with high speed, considering that contact between the ultrasound probe and the soft tissue may lead to finite deformation. On the basis of our theoretical analysis and numerical simulations, we propose an inverse approach to infer both the anisotropic and hyperelastic parameters of incompressible transversely isotropic (TI) soft materials. Finally, we investigate the properties of the solutions to the inverse problem by deriving the condition numbers in analytical form and performing numerical experiments. In Part II of the paper, both ex vivo and in vivo experiments are conducted to demonstrate the applicability of the inverse method in practical use.

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