论文标题
用于合成纳米复合膜的氧化石墨烯氧化石墨烯功能化策略：生物医学域中的电纺涂层
Doped graphene oxide functionalization strategy for synthesis of nanocomposite membranes: electrospun coatings in biomedical field application
论文作者
论文摘要
由2-甲基丙烯酰氧甲基乙基磷酸胆碱和丁基甲基丙烯酸酯共聚物（MPC-CO-BMA）制成的血管支架涂层（MPC-CO-BMA），也称为（PMB），用官能化和氮掺杂的氧化石墨烯（F-NRGO）呈现。由于氮掺杂降低的氧化石墨烯（NRGO）负电荷引起的该膜具有废除低密度脂蛋白（LDL）的能力，在特定条件下是动脉粥样硬化疾病的主要原因。 NRGO功能化过程详细介绍了NRGO和PMB之间的牢固键，避免了NRGO板从膜上脱离。共聚物合成的特征是FTIR的特征，F-NRGO和PMB之间的化学键证明了XPS和HNMR证明。此外，模拟血流条件的简化测试库证明了膜上的NRGO功能化效果。对于静电纺丝过程，最佳参数为14.5 kV的电压，流速为0.3 ml/h，这会导致膜的更好特性。 DMA结果证实，在机械性能方面，F-NRGO的最佳增强百分比为0.1 wt％，AFM图像表明纤维上存在F-NRGO板。最后，接触角揭示了对LDL的排斥反应，这种行为有望对诸如心血管涂层支架等应用。
An electrospun membrane for vascular stent coating made of 2-methacryloyloxyethyl phosphorylcholine and butyl methacrylate copolymer (MPC-co-BMA), also known as (PMB), reinforced with functionalized and nitrogen doped reduced graphene oxide (f-NrGO) is presented. This membrane due to the nitrogen doped reduced graphene oxide (NrGO) negative electric charge has the capacity to repeal low density lipoproteins (LDL), which under specific conditions are the main cause of atherosclerotic disease. The NrGO functionalization process is detailed, as it creates strong bonds between NrGO and PMB, avoiding NrGO sheets to detach from the membrane. The copolymer synthesis was characterized by FTIR and chemical bonds between f-NrGO and PMB were proved by XPS and HNMR. Additionally, a simplified test bank that simulates blood flow conditions demonstrated the NrGO functionalization effect over the membrane. For the electrospinning process, optimal parameters were a voltage of 14.5 kV, and a flow rate of 0.3 mL/h, which lead to better properties of the membrane for the application. DMA results confirmed that the best reinforcement percentage of f-NrGO in terms of mechanical properties was 0.1 wt% and AFM images indicated the presence of the f-NrGO sheets over the fibers. Finally, the contact angle revealed the repulsion response to LDL, such behavior is promising to applications like cardiovascular coated stents.
