论文标题
受体聚类对大肠杆菌趋化性性能的影响：传感与适应性
Effect of receptor clustering on chemotactic performance of Escherichia coli: sensing versus adaptation
论文作者
论文摘要
我们展示了感应和适应之间的竞争如何使用详细的理论模型中的广泛数值模拟导致大肠杆菌趋化性的性能峰。受体聚类扩大了来自配体结合的输入信号，从而提高了趋化效率。但是，由于集群数量减少，大型集群也会引起总活性的大波动。因此，活性及其奔跑的动力现在由甲基化水平控制，甲基化水平是适应模块的一部分，而不是配体结合。这降低了趋化效率。
We show how the competition between sensing and adaptation can result in a performance peak in E.coli chemotaxis using extensive numerical simulations in a detailed theoretical model. Receptor clustering amplifies the input signal coming from ligand binding which enhances chemotactic efficiency. But large clusters also induce large fluctuations in total activity since the number of clusters go down. The activity and hence the run-tumble motility now gets controlled by methylation levels which are part of adaptation module, rather than ligand binding. This reduces chemotactic efficiency.
