论文标题
信息传输在蜂窝通信中的功效
Efficacy of information transmission in cellular communication
论文作者
论文摘要
间和细胞内信号对于单个细胞执行各种生理任务并准确响应其环境变化至关重要。信号传导是通过可扩散的分子进行的，其运输通常通过提供方向对流的活动过程来帮助。扩散和对流如何共同影响细胞信号过程中信息传递的准确性，但研究的研究较少。为此，我们研究了一个一维细胞信号传导模型，并计算互信息（MI）作为信息传输的量度。我们发现，仅当系统参数导致小于一个大于1时，信息传输的疗效才会通过对流提高。有趣的是，MI表现出非平凡的缩放，其特征是三个不同的方案。我们证明，观察到的MI对信号分子的传输特性的依赖性对细胞通信具有重要的后果。
Inter and intra-cellular signaling are essential for individual cells to execute various physiological tasks and accurately respond to changes in their environment. Signaling is carried out via diffusible molecules, the transport of which is often aided by active processes that provide directional advection. How diffusion and advection together impact the accuracy of information transmission during cell signaling remains less studied. To this end, we study a one-dimensional model of cell signaling and compute the mutual information (MI) as a measure of information transmission. We find that the efficacy of the information transmission improves with advection only when the system parameters result in Peclet number greater than one. Intriguingly, MI exhibits nontrivial scaling with the Peclet number, characterized by three distinct regimes. We demonstrate that the observed dependence of MI on the transport properties of signaling molecules has important consequences on cellular communication.
