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Understanding the impact of the cladding tube structure on the overall guiding performance is crucial for designing single-mode, wide-band, and ultra low-loss nested hollow-core anti-resonant fiber (HC-ARF). Here we thoroughly investigate on how the propagation loss is affected by the nested elements when their geometry is realistic (i.e., non-ideal). Interestingly, it was found that the size rather than the shape of the nested elements, have a dominant role in the final loss performance of the HC-ARFs. We identify a unique 'V-shape' pattern for suppression of higher-order modes loss by optimizing free design parameters of HC-ARF. We find that a 5-tube nested HC-ARF has wider transmission window and better single-mode operation than 6-tube HC-ARF. We show that the propagation loss can be significantly improved by using anisotropic nested anti-resonant tubes elongated in the radial direction. Our simulations indicate that with this novel fiber design, a propagation loss as low as 0.11 dB/km at 1.55 $μ$m can be achieved. Our results provide design insights towards fully exploiting single-mode, wide-band, and ultra low-loss HC-ARF. In addition, the extraordinary optical properties of the proposed fiber can be beneficial for several applications such as future optical communication system, high energy light transport, extreme non-nonlinear optics and beyond.