论文标题
SARS-COV-2的进化趋势由均聚糖核苷酸重复序列推断
Evolutionary trend of SARS-CoV-2 inferred by the homopolymeric nucleotide repeats
论文作者
论文摘要
严重的急性呼吸道综合征冠状病毒2（SARS-COV-2）是当前全球Covid-19大流行病的病因，其中数百万生命丧生。了解冠状病毒的人畜共动性演变可能会为开发有效的疫苗，监测传输趋势并防止新的人畜共患感染提供见解。均聚糖核苷酸重复序列（HP）是最简单的串联重复序列，是真核基因组的无处不在的特征。然而，对冠状病毒基因组进化中的HP分布和作用进行了很少的研究。在这项研究中，我们表征了蝙蝠和人冠状病毒和SARS-COV-2变体的HP分布和趋势。结果表明，HPS中SARS-COV-2基因组丰富，并且在进化过程中增加了HP含量。尤其是，在人类宿主进化过程中，冠状病毒的HP聚（A/T）和冠状病毒的差异增加。 HP聚（A/T）和ploy-（C/G）的差异与宿主适应性和冠状病毒的毒力水平相关。因此，我们建议HP差异可以是冠状病毒的人畜共动性进化水平的定量度量。特殊的是，HP差异测量表明SARS-COV-2 OMICRON变体具有HP Poly-（A/T）和Ploy-（C/G）的高差异，这表明对人宿主具有很高的适应性。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current global COVID-19 pandemic, in which millions of lives have been lost. Understanding the zoonotic evolution of the coronavirus may provide insights for developing effective vaccines, monitoring the transmission trends, and preventing new zoonotic infections. Homopolymeric nucleotide repeats (HP), the most simple tandem repeats, are a ubiquitous feature of eukaryotic genomes. Yet the HP distributions and roles in coronavirus genome evolution are poorly investigated. In this study, we characterize the HP distributions and trends in the genomes of bat and human coronaviruses and SARS-CoV-2 variants. The results show that the SARS-CoV-2 genome is abundant in HPs, and has augmented HP contents during evolution. Especially, the disparity of HP poly-(A/T) and ploy-(C/G) of coronaviruses increases during the evolution in human hosts. The disparity of HP poly-(A/T) and ploy-(C/G) is correlated to host adaptation and the virulence level of the coronaviruses. Therefore, we propose that the HP disparity can be a quantitative measure for the zoonotic evolution levels of coronaviruses. Peculiarly, the HP disparity measure infers that SARS-CoV-2 Omicron variants have a high disparity of HP poly-(A/T) and ploy-(C/G), suggesting a high adaption to the human hosts.
