论文标题
基于平行谐振器的无线和无电池生物传感器，用于监测广泛的生物信号
A Wireless and Battery-free Biosensor Based on Parallel Resonators for Monitoring a Wide Range of Biosignals
论文作者
论文摘要
本文提出了一种新型的无线，无电池和无标签的生物传感器，用于用于微创和非侵入性介电常数，以用于应用诸如检测间质皮肤液中葡萄糖水平的应用。微型，完全被动的传感器基于两个对称平行的0.8毫米$^3 $ LC（电感器电容器）谐振器。每个电感器与其一个端子之一的导电板集成。被动传感器的主要领域在谐振器之外占主导地位，这在传感器之外产生了有效的电容，这与以前的研究所报道的那样，在以前的研究中，有效的电容仅限于谐振线之间的有效电容。在两种不同的情况下进一步分析了所提出的传感器，以改变有效电容的区域并测试其对压力监测的适用性，例如伤口监测；首先，通过重新定位两个谐振器之一，其次是用导电板代替其中一个谐振器。实验结果证实了拟议的被动传感器在检测水溶液中的葡萄糖浓度方面的性能，其灵敏度分别为500和46 kHz/（mg/dl），用于在0-500 mg/dl的葡萄糖范围内，分别为60-500 mg/dl的葡萄糖范围，分别为60 $ l。此外，通过重新定位一个谐振器，有效的电容位于被动传感器内部，使其适合伤口监测。结果表明，与敏感性在0.2-0.5 mm内的敏感性为2.5 $ \ times 10^3 $ MHz/mm之间的分离之间的变化相对于谐振器之间的分离变化，共振转移可以保持相当线性，这是在0.2-0.5 mm内的分离范围内，将分离视为感知伤口压力或愈合的主要因素。
This paper proposes a novel wireless, battery-free, and label-free biosensor for minimally invasive and non-invasive permittivity sensing for applications such as detecting glucose levels in the interstitial dermal fluid. The miniaturized, fully passive sensor is based on two symmetric parallel 0.8 mm$^3$ LC (inductor-capacitor) resonators. Each inductor is integrated with a conductive plate at one of its terminals. The passive sensor's main field is dominant outside the resonators, creating an effective capacitance outside the sensor, unlike reported in previous studies where the effective capacitance was limited to between the resonator lines. The proposed sensor was further analyzed under two different scenarios to change the region of effective capacitance and test its suitability for pressure monitoring, such as wound monitoring; first, by repositioning one of the two resonators, and second, by replacing one of the resonators with a conductive plate. The experimental results confirmed the proposed passive sensor's performance in detecting the glucose concentration in an aqueous solution with a sensitivity of 500 and 46 kHz/(mg/dL) for minimal invasive and non-invasive monitoring, respectively, within the glucose range of 0-500 mg/dL with volume sample requirements as low as 60 $μ$L. Further, by repositioning one of the resonators, the effective capacitance lies inside the passive sensor, making it suitable for wound monitoring. The results indicated that the resonance shift can be made fairly linear with respect to the variation in the separation between the resonators with a sensitivity of 2.5$\times 10^3$ MHz/mm within the separation range of 0.2-0.5 mm, considering separation as the main factor to sense the pressure or healing of the wound.
