论文标题
动态微观光学相干断层扫描，可视化气道的形态学和功能性微动术
Dynamic microscopic optical coherence tomography to visualize morphological and functional micro-anatomy of the airways
论文作者
论文摘要
成像气道组织，光学相干断层扫描（OCT）提供了组织结构的横截面图像，显示了纤毛运动和粘液分泌，但没有与分化单个细胞的足够对比。通过使用显微镜分辨率OCT（MOCT）图像的快速序列，OCT可以描绘出小信号波动（动态）OCT，并克服了由斑点噪声引起的对比度缺乏。通过这种方式，OCT可以在细胞水平上可视化气道形态，并允许跟踪免疫细胞的动态行为以及粘液的转运和分泌。在这里，我们证明MOCT通过将颞组织波动作为对比度（动态OCT）提供了在体内研究生理和病理组织过程的可能性。
Imaging airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells. By using fast sequences of microscopic resolution OCT (mOCT) images, OCT can picture small signal fluctuations (dynamic) OCT and overcomes the lack in contrast caused by speckle noise. In this way, OCT visualizes airway morphology on a cellular level and allows to track the dynamic behavior of immune cells, as well as mucus transport and secretion. Here, we demonstrate that mOCT, by using temporal tissue fluctuation as contrast (dynamic OCT), provides the possibility to study physiological and pathological tissue processes in vivo.
