论文标题
边界层中的脂质和脂质混合物：从润滑到骨关节炎
Lipids and lipid-mixtures in boundary layers: from hydration lubrication to osteoarthritis
论文作者
论文摘要
在界面上组装的单组磷脂酰胆碱（PC）脂质或脂质混合的磷脂头组周围的水合层极大地修饰了界面特性和相互作用。由于水合内的水分子被头部组紧密地固定，但在剪切上仍然非常流畅，露出高度水合头组阵列的边界脂质层可以在与相对的表面滑动时，可以提供有效的边界润滑。此外，周围液体中的任何自由脂质都可以治愈在边界PC层滑动过程中可能形成的缺陷。相似的边界脂质层有助于健康关节关节的润滑，承受压力和磨损保护功能。这篇综述对界面复合物的分子组成与基于脂质的边界层的润滑行为之间的关系进行了调查，这可能有益于设计边界润滑剂，以用于关节内注射以治疗早期OA。
The hydration layer surrounding the phosphocholine headgroups of single-component phosphatidylcholine (PC) lipids, or of lipid-mixtures, assembled at an interface greatly modifies the interfacial properties and interactions. As water molecules within the hydration layer are held tightly by the headgroup but are nonetheless very fluid upon shear, the boundary lipid layers, exposing the highly hydrated headgroup arrays, can provide efficient boundary lubrication when sliding against an opposing surface, at physiologically-high contact pressures. Additionally, any free lipids in the surrounding liquid can heal defects which may form during sliding on the boundary PC layer. Similar boundary lipid layers contribute to the lubricating, pressure-bearing, and wear-protection functions of healthy articular joints. This review presents a survey of the relationship between the molecular composition of the interfacial complex and the lubrication behavior of the lipid-based boundary layers, which could be beneficial for designing boundary lubricants for intra-articular injection for the treatment of early OA.
