论文标题
如何与IEEG一起研究因果脑网络？
How can I investigate causal brain networks with iEEG?
论文作者
论文摘要
尽管许多人类成像方法探究了大脑的结构和功能连通性，但以因果和方向方式研究皮质网络的技术至关重要，但有限。 IEEG的使用使几种方法可以直接表征功能连接的大脑区域，在某些情况下还建立了这些连接的方向性。在本章中，我们重点介绍了皮质皮质诱发电位（CCEP）的方法和应用，在该基础上，将电脉冲应用于一组颅内电极，从而在局部和远程区域产生电诱导的大脑反应。在本章中，CCEP首先是在用于定义皮质网络的常见大脑连接方法中的上下文，以及CCEP如何添加独特的信息。其次，讨论了使用CCEP时的实际和分析考虑因素。第三，我们回顾了CCEP的神经生理学以及CCEP的应用，包括探索功能和病理脑网络以及探测脑可塑性。最后，我们以讨论将来改善CCEP利用率的局限性，警告和方向的讨论结束。
While many human imaging methodologies probe the structural and functional connectivity of the brain, techniques to investigate cortical networks in a causal and directional manner are critical but limited. The use of iEEG enables several approaches to directly characterize brain regions that are functionally connected and in some cases also establish directionality of these connections. In this chapter we focus on the basis, method and application of the cortico-cortical evoked potential (CCEP), whereby electrical pulses applied to one set of intracranial electrodes yields an electrically-induced brain response at local and remote regions. In this chapter, CCEPs are first contextualized within common brain connectivity methods used to define cortical networks and how CCEP adds unique information. Second, the practical and analytical considerations when using CCEP are discussed. Third, we review the neurophysiology underlying CCEPs and the applications of CCEPs including exploring functional and pathological brain networks and probing brain plasticity. Finally, we end with a discussion of limitations, caveats, and directions to improve CCEP utilization in the future.
