论文标题
清醒和睡眠期间人类峰值活动的内在时间尺度
Intrinsic timescales of spiking activity in humans during wakefulness and sleep
论文作者
论文摘要
大脑中的信息处理需要随着时间的推移整合信息。如果在所需的时期内将信号维持在网络活动中，则可以实现此类集成。虽然短时间尺度被认为对刺激的快速响应有益，但长时间尺度促进了信息的存储和集成。我们从人体内侧颞叶中量化了内在的时间尺度。我们发现了从数十到数百毫秒的延长和高度多样化的时间尺度，尽管没有证据表明亚洲之间的差异。但是，值得注意的是，睡眠阶段之间的时间尺度有所不同，在慢波睡眠期间最长。这支持了以下假设：内部时间尺度是调整不同任务和认知状态要求的中心机制。
Information processing in the brain requires integration of information over time. Such an integration can be achieved if signals are maintained in the network activity for the required period, as quantified by the intrinsic timescale. While short timescales are considered beneficial for fast responses to stimuli, long timescales facilitate information storage and integration. We quantified intrinsic timescales from spiking activity in the medial temporal lobe of humans. We found extended and highly diverse timescales ranging from tens to hundreds of milliseconds, though with no evidence for differences between subareas. Notably, however, timescales differed between sleep stages and were longest during slow wave sleep. This supports the hypothesis that intrinsic timescales are a central mechanism to tune networks to the requirements of different tasks and cognitive states.
