论文标题
频场的射频扫描，用于寄生虫诱导的生物分子极化
Radio-Frequency Sweeps at μT Fields for Parahydrogen-Induced Polarization of Biomolecules
论文作者
论文摘要
$^{13} $ c标记的代谢产物的磁共振成像通过寄生虫诱导的极化（PHIP）增强，可以实时监测体内的过程。我们引入了一种强大的，易于实现的技术，用于使用$μ$ t场的绝热射频扫描将寄生虫衍生的单线序转移到13c磁化中。我们在实验上证明了该技术对几个分子的适用性，包括与代谢成像相关的一些分子，在某些情况下，我们显示出可实现的极化的显着改善，在某些情况下达到60％以上。此外，我们引入了一种现场选择性授权方案，其中氘包含在丙酮酸酯的耦合网络中，以提高极化转移的效率。通过强烈耦合的四极核引起的转移方案避免了放松，从而实现了这些改进。
Magnetic resonance imaging of $^{13}$C-labeled metabolites enhanced by parahydrogen-induced polarization (PHIP) can enable real-time monitoring of processes within the body. We introduce a robust, easily implementable technique for transferring parahydrogen-derived singlet order into 13C magnetization using adiabatic radio-frequency sweeps at $μ$T fields. We experimentally demonstrate the applicability of this technique to several molecules, including some molecules relevant for metabolic imaging, where we show significant improvements in the achievable polarization, in some cases reaching above 60%. Furthermore, we introduce a site-selective deuteration scheme, where deuterium is included in the coupling network of a pyruvate ester to enhance the efficiency of the polarization transfer. These improvements are enabled by the fact that the transfer protocol avoids relaxation induced by strongly coupled quadrupolar nuclei.
