论文标题
依赖发现比例的渐近不确定性$ t $检验
Asymptotic Uncertainty of False Discovery Proportion for Dependent $t$-Tests
论文作者
论文摘要
多重测试是高维统计推断中的基本问题。尽管已经提出了许多方法来控制虚假发现,但是当测试相互关联时,这仍然是一项具有挑战性的任务。为了克服这一挑战,已经提出了各种方法来估算在测试统计数据之间任意协方差下的错误发现率(FDR)和/或错误发现比例(FDP)。这些作品的一个有趣发现是,在弱依赖性下对FDP和FDR的估计与独立性相同。但是,Mei等。 (2021)指出,与FDR不同,FDP的渐近方差仍然与独立性差异很大,并且差异取决于测试统计数据之间的协方差结构。在本文中,当边际差异未知并且需要估算时,我们将此结果从$ z $ -tests扩展到$ t $检验。由于较弱的$ t $检验,我们表明FDP仍然收敛到与依赖性结构无关的固定数量,并进一步得出了FDP的渐近扩张和不确定性,从而导致与MEI等人相似的结果。 (2021)。此外,我们开发了一种近似方法来有效评估依赖$ t $检验的FDP的渐近方差。我们研究了FDP的渐近方差以及通过模拟和实际数据研究在不同依赖性结构下的估计量的性能以及其性能。
Multiple testing is a fundamental problem in high-dimensional statistical inference. Although many methods have been proposed to control false discoveries, it is still a challenging task when the tests are correlated to each other. To overcome this challenge, various methods have been proposed to estimate the false discovery rate (FDR) and/or the false discovery proportion (FDP) under arbitrary covariance among the test statistics. An interesting finding of these works is that the estimation of FDP and FDR under weak dependence is identical to that under independence. However, Mei et al. (2021) pointed out that unlike FDR, the asymptotic variance of FDP can still differ drastically from that under independence, and the difference depends on the covariance structure among the test statistics. In this paper, we further extend this result from $z$-tests to $t$-tests when the marginal variances are unknown and need to be estimated. With weakly dependent $t$-tests, we show that FDP still converges to a fixed quantity unrelated to the dependence structure, and further derive the asymptotic expansion and uncertainty of FDP leading to similar results as in Mei et al. (2021). In addition, we develop an approximation method to efficiently evaluate the asymptotic variance of FDP for dependent $t$-tests. We examine how the asymptotic variance of FDP varies as well as the performance of its estimators under different dependence structures through simulations and a real-data study.