论文标题
通过分布式热调节的CMOS高通量多模式安培DNA分析
On-CMOS High-Throughput Multi-Modal Amperometric DNA Analysis with Distributed Thermal Regulation
论文作者
论文摘要
准确的温度调节对于安培DNA分析至关重要，以实现高保真度，可靠性和吞吐量。在这项工作中，提出了用于CMOS多模式安培DNA分析的混合信号CMOS分布温度调节剂的9x6细胞阵列。支持三种DNA分析方法，包括恒定电位安培法（CPA），环状伏安法（CV）和阻抗光谱法（IS）。在不进行后处理的情况下，在标准CMOS技术中实现了电池加热和温度感应元件。使用比例综合衍生（PID）对照，可以将局部温度调节为20C和90C之间任何所需值的+/- 0.5C内。 PID算法，乘法和减法中的两个计算密集型操作是通过混合信号域中的单元内双斜率乘以ADC进行的，导致较小的面积和低功耗。超过95％的电路块在包括CPA，CV，IS和提议的温度调节模式在内的四种操作模式中共享。在0.13UM CMOS技术中制造的3mmx3mm CMOS原型已完全实验表征。每个通道占0.06mm2的面积，并从1.2V的电源中消耗42UW。所提出的分布式温度调节设计和混合信号PID实施可以应用于广泛的感官和其他应用。
Accurate temperature regulation is critical for amperometric DNA analysis to achieve high fidelity, reliability, and throughput. In this work, a 9x6 cell array of mixed-signal CMOS distributed temperature regulators for on-CMOS multi-modal amperometric DNA analysis is presented. Three DNA analysis methods are supported, including constant potential amperometry (CPA), cyclic voltammetry (CV), and impedance spectroscopy (IS). In-cell heating and temperature sensing elements are implemented in standard CMOS technology without post-processing. Using proportional-integral-derivative (PID) control, the local temperature can be regulated to within +/-0.5C of any desired value between 20C and 90C. The two computationally intensive operations in the PID algorithm, multiplication, and subtraction, are performed by an in-cell dual-slope multiplying ADC in the mixed-signal domain, resulting in a small area and low power consumption. Over 95% of the circuit blocks are synergistically shared among the four operating modes, including CPA, CV, IS, and the proposed temperature regulation mode. A 3mmx3mm CMOS prototype fabricated in a 0.13um CMOS technology has been fully experimentally characterized. Each channel occupies an area of 0.06mm2 and consumes 42uW from a 1.2V supply. The proposed distributed temperature regulation design and the mixed-signal PID implementation can be applied to a wide range of sensory and other applications.
