论文标题
监管基序：遗传计算的结构和功能构建基块
Regulatory motifs: structural and functional building blocks of genetic computation
论文作者
论文摘要
发展和维持生活需要大量计算。这是由基因调节网络完成的。但是我们对如何组织了该计算几乎没有理解。我表明，调节网络的结构和功能构建块之间存在直接的对应关系，我称之为监管基序。我根据本地网络结构来得出这些主题可以执行的功能范围的简单界限。我证明该范围是所有可能功能的一小部分，这严重限制了全局网络行为。该限制的一部分是由于监管图案可以实现的功能的冗余性 - 执行相同任务的方法有很多。监管主题有助于我们了解遗传计算的组织方式以及它可以实现的目标。
Developing and maintaining life requires a lot of computation. This is done by gene regulatory networks. But we have little understanding of how this computation is organized. I show that there is a direct correspondence between the structural and functional building blocks of regulatory networks, which I call regulatory motifs. I derive a simple bound on the range of function that these motifs can perform, in terms of the local network structure. I prove that this range is a small fraction of all possible functions, which severely constrains global network behavior. Part of this restriction is due to redundancy in the function that regulatory motifs can achieve - there are many ways to perform the same task. Regulatory motifs help us understanding how genetic computation is organized and what it can achieve.
