论文标题
肿瘤作为胚胎学现象及其对动物进化和癌症起源的影响。 I.肿瘤过程的介绍及其与细胞融合和种系的联系
The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation
论文作者
论文摘要
胚胎学在理解动物形式的演变中的决定性作用是建立在科学史上的。人们认识到，如果没有第一个胚胎的形成，多细胞的出现将是不可能的。我们推测，生物物理现象和Ediacaran海洋的周围环境有助于在第一个合子的核中选择肿瘤功能模块（NFM）。因此，在这里被理解为具有深远胚胎学意义的生物学现象的肿瘤过程，是一种进化引擎，有利于形成第一种胚胎和癌性疾病，并允许在进化过程中连贯创造和重现不同动物群体的身体形状。在本文中，我们对第一个胚胎发生的物理学及其对去除其他NFM成分（例如细胞外基质）的贡献进行了深入反思。 NFM组件，结构，动力学和来源的知识促进了我们对胚胎在进化辐射过程中通过肿瘤形式创造动物形式的众多可能性和不同创新的理解。肿瘤的发育途径起源于囊肿，并在哺乳动物和其他根尖组中合并。
The decisive role of Embryology in understanding the evolution of animal forms is founded and deeply rooted in the history of science. It is recognized that the emergence of multicellularity would not have been possible without the formation of the first embryo. We speculate that biophysical phenomena and the surrounding environment of the Ediacaran ocean were instrumental in co-opting a neoplastic functional module (NFM) within the nucleus of the first zygote. Thus, the neoplastic process, understood here as a biological phenomenon with profound embryologic implications, served as the evolutionary engine that favored the formation of the first embryo and cancerous diseases and allowed to coherently create and recreate body shapes in different animal groups during evolution. In this article, we provide a deep reflection on the Physics of the first embryogenesis and its contribution to the exaptation of additional NFM components, such as the extracellular matrix. Knowledge of NFM components, structure, dynamics, and origin advances our understanding of the numerous possibilities and different innovations that embryos have undergone to create animal forms via Neoplasia during evolutionary radiation. The developmental pathways of Neoplasia have their origins in ctenophores and were consolidated in mammals and other apical groups.
