论文标题
毛细血管中毛细血管的可见性：一种分析方法
Visibility of capillaries in turbid tissues: an analytical approach
论文作者
论文摘要
目的：对真皮和粘膜中毛细管环的可视化和监测对于各种临床应用，包括风湿病，早期癌症和冲击检测很有趣。但是，现有成像技术的局限性尚不清楚。因此，这项研究旨在阐明逼真的皮肤成像几何形状中地下缺陷可视化的特征性。方法：我们使用了一种扰动方法，用于在边界不匹配的浑浊组织中的光传播。缺陷被认为是浸入均匀培养基中的负光源，使用弥漫性近似描述。对比比用作图像质量指标。结果：我们已经开发了单点地下缺陷模型，并将其扩展到水平和垂直线性的线性不均匀性。特别是，我们获得了埋在一定深度（水平截断）的单点缺陷和无限线性缺陷的明确分析表达式，这允许直接实验验证。结论：在设计和优化成像系统时，开发的方法可用于快速粗略估计。
Purpose: Visualization and monitoring of capillary loops in dermis and mucosa are interesting for various clinical applications, including rheumatology, early cancer, and shock detection. However, the limitations of existing imaging technologies are not well understood. Therefore, this study aimed to elucidate peculiarities of the subsurface defect visualization in realistic skin imaging geometries. Methods: We used a perturbation approach for the light propagation in turbid tissues with mismatched boundaries. Defects were considered as negative light sources immersed in homogeneous media, which was described using diffuse approximation. The contrast ratio was used as an image quality metric. Results: We have developed the single point subsurface defect model and extended it to horizontally- and vertically-arranged linear inhomogeneities. In particular, we have obtained explicit analytical expressions for the single point defect and the infinite linear defect buried at a certain depth (horizontally-arranged), which allows direct experimental verification. Conclusions: The developed approach can be used for quick rough estimates while designing and optimizing imaging systems.
