论文标题
最佳控制淀粉样蛋白纤维化
Towards Optimal Control of Amyloid Fibrillation
论文作者
论文摘要
EGCG作为淀粉样蛋白抑制剂的代表，通过直接降解成熟的原纤维来表现出对ABETA纤颤的有希望的能力。以前的大多数研究都集中在其功能机制上，同时很少考虑其最佳剂量。为了解决这个关键问题，我们指的是淀粉样蛋白纤颤和抑制的广义物流模型，并采用最佳控制理论以平衡抑制剂的有效性和成本（或毒性）。分析抑制剂的最佳控制轨迹是根据模型参数的影响，最佳控制策略和几种传统药物给药策略之间的差异进行了分析求解的。我们的结果将阐明诊所中淀粉样蛋白抑制剂的合理用法。
EGCG, as a representative of amyloid inhibitors, has shown a promising ability against Abeta fibrillation by directly degradating the mature fibrils. Most previous studies have been focusing on its functional mechanisms, meanwhile its optimal dosage has been seldom considered. To solve this critical issue, we refer to the generalized Logistics model for amyloid fibrillation and inhibition and adopt the optimal control theory to balance the effectiveness and cost (or toxicity) of inhibitors. The optimal control trajectory of inhibitors is analytically solved, based on which the influence of model parameters, the difference between the optimal control strategy and several traditional drug dosing strategies are systematically compared and validated through experiments. Our results will shed light on the rational usage of amyloid inhibitors in clinic.
