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This paper studies the control problem for safety-critical multi-agent systems based on quadratic programming (QP). Each controlled agent is modeled as a cascade connection of an integrator and an uncertain nonlinear actuation system. In particular, the integrator represents the position-velocity relation, and the actuation system describes the dynamic response of the actual velocity to the velocity reference signal. The notion of input-to-output stability (IOS) is employed to characterize the essential velocity-tracking capability of the actuation system. The uncertain actuation dynamics may cause infeasibility or discontinuous solutions of QP algorithms for collision avoidance. Also, the interaction between the controlled integrator and the uncertain actuation dynamics may lead to significant robustness issues. By using nonlinear control methods and numerical optimization methods, this paper first contributes a new feasible-set reshaping technique and a refined QP algorithm for feasibility, robustness, and local Lipschitz continuity. Then, we present a nonlinear small-gain analysis to handle the inherent interaction for guaranteed safety of the closed-loop multi-agent system. The proposed methods are illustrated by numerical simulations and a physical experiment.