论文标题
通过与低级别Hankel模型解耦的NMR分辨率增强
Resolution enhancement of NMR by decoupling with low-rank Hankel model
论文作者
论文摘要
核磁共振（NMR）光谱已成为生物化学和医学的强大工具。尽管J耦合带有基本的结构信息，但它也可能限制光谱分辨率。同性核解耦仍然是一个具有挑战性的问题。在这项工作中，我们引入了一种新方法，该方法使用特定的耦合值作为先验知识，以及指数NMR信号的Hankel属性，以使用低级别方法实现宽带异核解耦。我们对合成和现实的HMQC光谱的结果表明，所提出的方法不仅可以通过解耦有效增强分辨率，而且还保持灵敏度并抑制光谱伪像。该方法可以与非均匀的采样相结合，这意味着可以进一步改进分辨率，而无需任何额外的收购时间
Nuclear magnetic resonance (NMR) spectroscopy has become a formidable tool for biochemistry and medicine. Although J-coupling carries essential structural information it may also limit the spectral resolution. Homonuclear decoupling remains a challenging problem. In this work, we introduce a new approach that uses a specific coupling value as prior knowledge, and Hankel property of exponential NMR signal to achieve the broadband heteronuclear decoupling using the low-rank method. Our results on synthetic and realistic HMQC spectra demonstrate that the proposed method not only effectively enhances resolution by decoupling, but also maintains sensitivity and suppresses spectral artefacts. The approach can be combined with the non-uniform sampling, which means that the resolution can be further improved without any extra acquisition time
