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Roundoff error problems have occurred frequently in interpolation methods of time-fractional equations, which can lead to undesirable results such as the failure of optimal convergence. These problems are essentially caused by catastrophic cancellations. Currently, a feasible way to avoid these cancellations is using the Gauss--Kronrod quadrature to approximate the integral formulas of coefficients rather than computing the explicit formulas directly for example in the L2-type methods. This nevertheless increases computational cost and arises additional integration errors. In this work, a new framework to handle catastrophic cancellations is proposed, in particular, in the computation of the coefficients for standard and fast L2-type methods on general nonuniform meshes. We propose a concept of $δ$-cancellation and then some threshold conditions ensuring that $δ$-cancellations will not happen. If the threshold conditions are not satisfied, a Taylor-expansion technique is proposed to avoid $δ$-cancellation. Numerical experiments show that our proposed method performs as accurate as the Gauss--Kronrod quadrature method and meanwhile much more efficient. This enables us to complete long time simulations with hundreds of thousands of time steps in short time.