论文标题
细胞必须如何准确测量信号分子的浓度？
How accurately must cells measure the concentrations of signaling molecules?
论文作者
论文摘要
与生物体相关的信息通常由细胞内特定分子的浓度表示。作为外部观察者，我们现在可以精确地测量这些浓度，但是单元格的机制必须更加嘈杂。我们表明，在某些范围内，这些浓度测量值的信息能力与捕获的相关信息的数量（信息瓶颈问题的一种版本）之间存在普遍的权衡。定量地确认了这种普遍的权衡，以分析发育中的苍蝇胚胎中差距基因编码的位置信息。
Information of relevance to the organism often is represented by the concentrations of particular molecules inside a cell. As outside observers we can now measure these concentrations precisely, but the cell's own mechanisms must be noisier. We show that, in certain limits, there is a universal tradeoff between the information capacity of these concentration measurements and the amount of relevant information that is captured, a version of the information bottleneck problem. This universal tradeoff is confirmed, quantitatively, in an analysis of the positional information encoded by the gap genes in the developing fly embryo.
