论文标题
列表模式的分辨率恢复MLEM重建动态心脏SPECT系统
Resolution recovery on list mode MLEM reconstruction for Dynamic Cardiac SPECT system
论文作者
论文摘要
动态心脏SPECT(DC-spect)系统正在马萨诸塞州综合医院开发,具有静态的心脏焦点不对称的几何形状,实现了同时高分辨率和高灵敏度成像。在具有不同探测器头的DC-Spect的14个设计迭代中,系统灵敏度和系统分辨率,当前版本被制造为10 mm FWHM几何分辨率(无分辨率恢复)和0.07%的灵敏度;与传统的双头伽玛相机相比,这是1.5倍的分辨率增益和7倍的灵敏度增益。这项工作通过实现具有列表模式MLEM重建的空间变异点扩展函数(SV-PSF)来改进成像分辨率。 PSF反卷积的分辨率恢复方法在列表模式MLEM重建的DC-spect上进行了验证。包括空间不变的PSF作为附加测试,以显示PSF建模对重建图像质量的准确性的影响。我们将MLEM重建与PSF反卷积进行比较。分析模型用于计算系统响应,并将结果与基于蒙特卡洛(MC)方法进行比较。结果表明,使用PSF建模,改善了重建图像的质量,并且DC-Spect系统可以达到4.5 mm中央空间分辨率,平均计数为795/(S*MBQ)。结果表明,与黄金标准GE Discovery 570C性能相比(空间分辨率7 mm,平均为460个计数/s*MBQ,中央分辨率5.8 mm)。 PSF反卷积的影响很大,与MC模拟系统矩阵相比,重建的图像质量的改进更为明显,其采样大小与模拟相同。
The Dynamic Cardiac SPECT (DC-SPECT) system is being developed at the Massachusetts General Hospital, featuring a static cardio focus asymmetrical geometry enabling simultaneous high resolution and high sensitivity imaging. Among 14 design iterations of the DC-SPECT with varying number of detector heads, system sensitivity and system resolution, the current version being fabricated features 10 mm FWHM geometrical resolution (without resolution recovery) and 0.07% sensitivity; this is 1.5x resolution gain and 7x sensitivity gain compared to a conventional dual head gamma camera. This work presents improvement in imaging resolution by implementing a spatially variant point spread function (SV-PSF) with list mode MLEM reconstruction. A resolution recovery method by PSF deconvolution is validated on list mode MLEM reconstruction for DC-SPECT. A spatial invariant PSF is included as an additional test to show the influence of the accuracy of PSF modelling on the reconstructed image quality. We compare the MLEM reconstruction with and without PSF deconvolution; an analytic model is used for the calculation of system response, and the results are compared to Monte Carlo (MC) based methods. Results show that with PSF modelling applied, the quality of the reconstructed image is improved, and the DC-SPECT system can achieve a 4.5 mm central spatial resolution with average 795 counts/(s*Mbq). The results show substantial improvement over the gold standard GE Discovery 570c performance (spatial resolution 7 mm with an average 460 counts/s*MBq, central resolution 5.8 mm). The impact of PSF deconvolution is significant, and the improvements of the reconstructed image quality is more evident compared to MC simulated system matrix with the same sampling size as in simulation.